ABSTRACT
BACKGROUND/AIMS: To report gastric emptying scintigraphy, normal values should be established for a specific protocol. The aim of this study was to provide normal gastric emptying values and determine factors affecting gastric emptying using Asian rice-based meal in healthy volunteers. METHODS: One hundred and ninety-two healthy volunteers were included at 7 tertiary care centers across Thailand. Gastric emptying scintigraphy was acquired in 45 degree left anterior oblique view immediately after ingestion of a 267 kcal steamed-rice with technetium-99m labeled-microwaved egg meal with 100 mL water for up to 4 hours. RESULTS: One hundred and eighty-nine volunteers (99 females, age 43 +/- 14 years) completed the study. The medians (5-95th percentiles) of lag time, gastric emptying half time (GE T1/2) and percent gastric retentions at 2 and 4 hours for all volunteers were 18.6 (0.5-39.1) minutes, 68.7 (45.1-107.8) minutes, 16.3% (2.7-49.8%) and 1.1% (0.2-8.8%), respectively. Female volunteers had significantly slower gastric emptying compared to male (GE T1/2, 74 [48-115] minutes vs. 63 (41-96) minutes; P < 0.05). Female volunteers who were in luteal phase of menstrual cycle had significantly slower gastric emptying compared to those in follicular phase or menopausal status (GE T1/2, 85 [66-102] mintes vs. 69 [50-120] minutes or 72 [47-109] minutes, P < 0.05). All of smoking volunteers were male. Smoker male volunteers had significantly faster gastric emptying compared to non-smoker males (GE T1/2, 56 [44-80] minutes vs. 67 [44-100] minutes, P < 0.05). Age, body mass index and alcohol consumption habits did not affect gastric emptying values. CONCLUSIONS: A steamed-rice with microwaved egg meal was well tolerated by healthy volunteers. Gender, menstrual status and smoking status were found to affect solid gastric emptying.
Subject(s)
Female , Humans , Male , Alcohol Drinking , Asian People , Body Mass Index , Eating , Follicular Phase , Gastric Emptying , Healthy Volunteers , Luteal Phase , Meals , Menstrual Cycle , Mentha , Ovum , Radionuclide Imaging , Reference Values , Smoke , Smoking , Tertiary Care Centers , Thailand , Volunteers , WaterABSTRACT
Liver abscess is a common disease in Thailand. Most of liver abscesses are pyogenic or amoebic in orgin. However pyogenic abscess cause by Pseudomonas pseudomaillei (Melioidosis abscess) is among the most common pathogen in Northeast Thailand. Antibiotic treatemtn of melioidosis liver abscess is generally different from other pyogenic abscess. The criteria to differentiation between amoebic, melioidosis and other pyogenic liver abscess is important in clinical practice especially in Northeast of Thailand, where the incidence of melioidosis is hith.
ABSTRACT
“POEMS Syndrome” associated with plasma cell dyscrasia, is an acronym that stands for uncommon syndrome involving multisystem. The major features are chronic progressive sensorimotor polyneuropathy, organomegaly (mainly hepatomegaly and lymphadenopathy) endocrinopathy (especially gonadal failure and diabetes mellitus), monoclonal gammopathy and skin changes. In typical case, papilledema, high CSF pressure and CSF potein, anasarca and clubbing of fingers are found. Most cases were reported from Japan, and rarely reported from United States, Europe and other parts of Asia. We report a Thai woman who initially presented with chronic diarrhea, edema and kin changes, then the other complete features of POEMS syndrome were revealed later.
ABSTRACT
Dyspepsis is an extremely common presenting symptom with a prevalence in the community of approximately 30% and may be an early symptom of a serious illness. This prospective data analysis aims to determine the etiology of the patient who present with dyspepsia in Srinagarind Hospital. 208 patients were studied with completed a structured history questionnaire and completed investigation with complete blood count, stool examination, liver function test, HbsAg, HbsAb, ultrasonography of the abdomen and endoscopy. The most common cause is non-ulcer dyspepsia (53.27%). There were peptic ulcer disease in 26.44%, hepatobiliary disease in 16.83% and combined peptic ulcer disease and hepatobiliary disease in 3.37%. Malignant cause of dyspepsia which we found in this series is tumor of the liver.
ABSTRACT
Chronic diarrhoea can occur from various causes, and it is one of the clinical manifestations which creates many problems in both diagnostic and therpeutic management. Its etologic factors vary from one geographic region to another. Retrospective study of 41 admitted patients in Srinagarind Hospital due to chronic diarrhoea during January 1983 and July 1987 was performed. The most common cause is parasitic infestation (53.85%), follow by irritable bowel syndrome, tumor, intestinal tubrculosis, bacterial infection and unknown cause respectively. Among these 78% responsed well to treatment 17% were not improved and mortality rate was 4.8%
ABSTRACT
Lithium is an effective therapeutic agent for the manic phase of manic depressive disease. The average daily dosage for acute manic states is 300 to 3,600 mg. of lithium carbonate. Careful monitoring of serum level and clinical signs of lithium intoxication are indicated because lithium intoxication is being encountered more frequently, as the drug is administered more often, even when the serum levels are within the acceptable range of safety. Overdosage of lithium can cause serious intoxication and several fatalities have been reported. There is on specific antidode, and treatment has been limited to supportive measures and attempts to increase the removal of lithium from the body. Saline infusion with or without forced diuresis and alkalinization of the urine is usually sufficient. In the following case, severe lithium intoxication with acute renal failure was treated with hemodialysis and the patient was completely recovery.